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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
Authors:Mathew JK Jones  Camille Gelot  Stephanie Munk  Amnon Koren  Yoshitaka Kawasoe  Kelly A George  Ruth E Santos  Jesper V Olsen  Steven A McCarroll  Mark G Frattini  Tatsuro S Takahashi  Prasad V Jallepalli
Institution:1. Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. University of Copenhagen and Novo Nordisk Foundation Center for Protein Research, Copenhagen 2200, Denmark;3. Cornell University, Department of Molecular Biology and Genetics, Ithaca, NY 14853, USA;4. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;5. Graduate School of Science, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan;6. Division of Hematology/Oncology, Columbia University Medical Center, New York, NY 10032, USA;7. The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia
Abstract:
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  • Keywords:DDK  Cdc7  MERIT40  PDS5B  DNA replication  ATR  phosphoproteomics  chemical genetics
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