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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis |
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| Authors: | Radha Mukherjee Kiran G. Vanaja Jacob A. Boyer Sunyana Gadal Hilla Solomon Sarat Chandarlapaty Andre Levchenko Neal Rosen |
| Affiliation: | 1. Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Yale Systems Biology Institute, Yale University, Orange, CT 06477, USA;3. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA |
| Abstract: |  |
| Keywords: | PI3K signaling negative feedback PTEN regulation mTOR 4E-BP PTEN translation growth factor signaling resistance to PI3K inhibition BYL-719 computational model of PI3K signaling |
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