| 多糖-药物轭合物的研究与展望 |
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| 引用本文： | 张庆,徐溢,曹坤,牟秀霓,张晓凤,吕君江. 多糖-药物轭合物的研究与展望[J]. 生物化学与生物物理进展, 2017, 44(4): 303-315 |
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| 作者姓名： | 张庆 徐溢 曹坤 牟秀霓 张晓凤 吕君江 |
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| 作者单位： | 重庆大学化学化工学院，重庆 400030；微纳系统与新材料国际联合研发中心，重庆 400030,重庆大学化学化工学院，重庆 400030；微纳系统与新材料国际联合研发中心，重庆 400030；新型微纳器件与系统技术重点学科实验室，重庆 400030,重庆大学化学化工学院，重庆 400030；微纳系统与新材料国际联合研发中心，重庆 400030,重庆大学化学化工学院，重庆 400030；微纳系统与新材料国际联合研发中心，重庆 400030,重庆大学化学化工学院，重庆 400030；微纳系统与新材料国际联合研发中心，重庆 400030,重庆大学化学化工学院，重庆 400030；微纳系统与新材料国际联合研发中心，重庆 400030 |
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| 基金项目： | 国家自然科学基金(21375156), 重庆市科委前沿基础研究重点项目(cstc2015jcyjBX0010)和重庆市科委创新项目(cstc2015shmszx00014)资助 |
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| 摘 要： | 多糖类物质作为赋形剂在药物制剂中已被广泛使用,多糖结构中包含了多种活性基团如羟基、羧基、氨基等,具有良好的亲水性、生物可降解性以及生物安全性,使其在聚合物-药物轭合物的构建中成为理想的载体材料.目前天然的多糖大分子及其衍生物作为药物载体的研究方兴未艾,以多糖为载体的聚合物-药物轭合物在定位或靶向给药、组织工程、生物黏附等领域也备受关注.本文以天然多糖-药物轭合物的研究现状为切入点,总结归纳了多糖-药物轭合物的设计与构建途径,介绍了其在药物传递中的应用,讨论并分析了多糖在轭合物体系中的角色和发挥的作用,对以多糖为载体的聚合物-药物轭合物发展的方向予以了讨论.
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| 关 键 词： | 天然多糖，多糖-药物轭合物，药物载体，药物传递 |
| 收稿时间： | 2016-10-08 |
| 修稿时间： | 2017-03-13 |
The Progress and Prospects of Polysaccharide-drug Conjugates |
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| ZHANG Qing,XU Yi,CAO Kun,MU Xiu-Ni,ZHANG Xiao-Feng and LV Jun-Jiang. The Progress and Prospects of Polysaccharide-drug Conjugates[J]. Progress In Biochemistry and Biophysics, 2017, 44(4): 303-315 |
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| Authors: | ZHANG Qing XU Yi CAO Kun MU Xiu-Ni ZHANG Xiao-Feng LV Jun-Jiang |
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| Affiliation: | School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; International R & D Center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing 400030, China,School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; International R & D Center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing 400030, China; Key Disciplines Laboratory of Novel Micro-nano Devices and System Technology, Chongqing University, Chongqing 400030, China,School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; International R & D Center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing 400030, China,School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; International R & D Center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing 400030, China,School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; International R & D Center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing 400030, China and School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China; International R & D Center of Micro-nano Systems and New Materials Technology, Chongqing University, Chongqing 400030, China |
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| Abstract: | Natural polysaccharides such as starch, cyclodextrin and so on are widely used as excipients in pharmacy. These biodegradable, biocompatible, and hydrophilic polysaccharides contain different functional groups (such as hydroxyl, carboxylic acid, amino) that make them ideal for conjugation. In recent years, the utilization of polysaccharides and their derivatives in drug delivery is in the ascendant, these polysaccharides based polymer-drug conjugates are applied to the fields of targeted drug delivery, tissue engineering and bioadhesive technology, and other biomedical applications. This paper presented an overview of the research status of polysaccharide-drug conjugates, including the design and formulation of conjugates, and their applications in drug delivery system. In addition, the functional roles of polysaccharide in conjugate system and the future direction in the developments of polysaccharide-drug conjugates were also been mentioned. |
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| Keywords: | natural polysacchairde polysaccharide-drug conjugate drug carrier drug delivery |
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