| 丝裂霉素促进活性氧自由基生成的研究 |
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| 引用本文： | 鲁纯素,赵会英,史录文.丝裂霉素促进活性氧自由基生成的研究[J].中国生物化学与分子生物学报,1989,5(6):532-536. |
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| 作者姓名： | 鲁纯素 赵会英 史录文 |
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| 作者单位： | 北京医科大学药学院物理化学教研室 北京
(鲁纯素)，北京医科大学药学院 82级毕业生
(赵会英)，北京医科大学药学院 82级毕业生(史录文) |
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| 摘 要： | 本文探讨了抗癌药丝裂霉素对活性氧自由基,超氧负离子自由基(O_2~-),羟自由基(OH)生成反应的作用,实验表明,丝裂霉素对O_2~-及OH的生成有明显的促进作用,其作用随着丝裂霉素浓度的增加而加强。分别测定了它对两种自由基生成反应的促进率。
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| 关 键 词： | 练裂霉素 超氧负离子自由基 羟自由基 促进作用 |
| 收稿时间： | 1989-12-20 |
Effects of Mitomycin C on the Formation of Active Oxygen Free Radical |
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| Lu,Chun-su Zhao,Hui-ying Shi,Lu-wen.Effects of Mitomycin C on the Formation of Active Oxygen Free Radical[J].Chinese Journal of Biochemistry and Molecular Biology,1989,5(6):532-536. |
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| Authors: | Lu Chun-su Zhao Hui-ying Shi Lu-wen |
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| Institution: | (Department of Physical Chemisity, School of Pharmaceutical Sciences, Beijing Medical University, Beijing |
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| Abstract: | Mitomycin C is a quinone-containing anticancer drug. Investigation on the mechanism of anticancer activity of mitomycin C shows that it interferes with DNA and RNA replication directly or indirectly through the action of oxygen-dependent radicals, 02- and·OH. In our studies O2- is generated and determinated by KO2 with NBT in DMSO system,·OH is generated and determinated by Fe(11) EDTA with H2O2 in aqueous solutions on the change of the fluorescence. Mitomycin C was found to be able to promote the generation of O2- and·OH. The promoting ratio Ps% and Pk% of O2- and·OH by mitomycin C were maasured. |
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| Keywords: | Mitomycin C Superoxide free radical Hydroxyl free radical |
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