Culturability and Secondary Metabolite Diversity of Extreme Microbes: Expanding Contribution of Deep Sea and Deep-Sea Vent Microbes to Natural Product Discovery |
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Authors: | Robin K Pettit |
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Institution: | (1) Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-2404, USA |
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Abstract: | Microbes from extreme environments do not necessarily require extreme culture conditions. Perhaps the most extreme environments
known, deep-sea hydrothermal vent sites, support an incredible array of archaea, bacteria, and fungi, many of which have now
been cultured. Microbes cultured from extreme environments have not disappointed in the natural products arena; diverse bioactive
secondary metabolites have been isolated from cultured extreme-tolerant microbes, extremophiles, and deep-sea microbes. The
contribution of vent microbes to our arsenal of natural products will likely grow, given the culturability of vent microbes;
their metabolic, physiologic, and phylogenetic diversity; numerous reports of bioactive natural products from microbes inhabiting
high acid, high temperature, or high pressure environments; and the recent isolation of new chroman derivatives and siderophores
from deep-sea hydrothermal vent bacteria. |
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