THE COMPOSITION OF MYELIN FROM THE MUTANT MOUSE ''QUAKING'' |
| |
| Authors: | N. A. Gregson J. M. Oxberry |
| |
| Affiliation: | Department of Anatomy, Guy's Hospital Medical School, London and M.R.C. Membrane Biology Group, Department of Biochemistry, Charing Cross Hospital Medical School, London |
| |
| Abstract: | Abstract— Myelin was isolated from the brains of adult Quaking mice, a mutant showing a deficiency of myelin in the central nervous system, and normal controls. The mutant myelin was found to have a higher flotation density than that of the control and showed marked differences in lipid composition. The myelin from Quaking mice was found to be deficient in cerebroside and ethanolamine phospholipid. Acrylamide gel electrophoresis of total myelin protein demonstrated a pronounced deficiency of proteolipid protein. The activity of cyclic 2',3'-AMP phosphohydrolase was normal. |
| |
| Keywords: | |
|
|
