Influence of angiotensins (I,II, & III), bradykinin and arachidonic acid on renomedullary PGE production in vitro |
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| Authors: | Mukhtar Anees Pat Sweet Siang-Yong Tan Patrick J Mulrow |
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| Institution: | Section of Endocrinology Department of Medicine Medical College of Ohio Toledo, Ohio 43699 USA |
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| Abstract: | Renomedullary tissue from rabbit or rat was incubated with angiotensin I, II, III, arachidonic acid, bradykinin, indomethacin and meclofenamate to study their effect on PGE2 production.Arachidonic acid and bradykinin enhanced PGE2 production significantly. Indomethacin and meclofenamate inhibited PGE2 production by more than 70%. Angiotensin I, II and III did not influence PGE2 production. These results suggest that bradykinin and arachidonic acid stimulate PGE2 production by a direct cellular action whereas the angiotensins do not. |
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