Effects of prostacyclin on the canine isolated basilar artery |
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| Authors: | Charles E Chapleau Richard P White |
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| Institution: | 1. Department of Neurosurgery, University of Tennessee Center for the Health Sciences, Memphis, TN 38163 USA;2. Department of Pharmacology, University of Tennessee Center for the Health Sciences, Memphis, TN 38163 USA |
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| Abstract: | Prostacyclin (PGI2) produced a biphasic response in canine isolated basilar arteries. In low doses (1 × 10?8M?1 × 10?7M) PGI2 caused a slight but consistent relaxation of resting muscle tone. In low concentrations (1 × 10?8M?1 × 10?6M) PGI2 antagonized muscle contractions caused by serotonin or prostaglandin (PG) F2α. This relaxant effect with low doses of PGI2 on the isolated cerebral artery contrasts with findings obtained with other PGs and supports the hypothesis that PGI2 is a mediator of vasodilatation. However, in 1 × 10?5M concentrations PGI2 contracted the arterial muscle and did not antagonize contractions induced by serotonin or PGF2α. |
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