Uptake and turnover of65Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions |
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Authors: | Jan Wensink Clement H Paays Cornelis J A van den Hamer |
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Institution: | (1) Department of Radiochemistry, Interuniversity Reactor Institute, Mekelweg 15, 2629 JB Delft, The Netherlands |
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Abstract: | After a single injection,65Zn is slowly taken up by the brain of the rat to a maximum after 7 d, followed by a turnover phase, with a half-time of about
3 wk. In the brain of rats on a zinc-deficient diet, the65Zn content in the brain continued to increase up to 30 d after the injection.
The uptake and turnover phases in six different subcellular fractions of the brain showed a pattern similar to that of the
whole brain in both the control and zinc-deficient rats. There was no internal redistribution of65Zn in the brain under conditions of progressive zinc deficiency.
The results are discussed in a model for zinc homeostasis in the brain. |
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Keywords: | 65Zn metabolism in brain subcellular fractions zinc deficiency effect on metabolism of65Zn in brain subcellular fractions brain metabolism of65Zn in subcellular fractions |
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