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Combined Vitamins B12b and C Induce the Glutathione Depletion and the Death of Epidermoid Human Larynx Carcinoma Cells HEp-2 |
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| Authors: | Vladimir S. Akatov Yury V. Evtodienko Violetta V. Leshchenko Vera V. Teplova Margarita M. Potselueva Alexey G. Kruglov Enric I. Lezhnev Raisa I. Yakubovskaya |
| Affiliation: | (1) Laboratory of Cytotechnology, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia;(2) Moscow Hertsen Oncological Institute, Russian Academy of Medical Sciences, Russia |
| Abstract: | The combination of hydroxocobalamin (vitamin B12b) and ascorbicacid (vitamin C) can cause the death of tumor cells at the concentrationsof the components at which they are nontoxic when administeredseparately. This cytotoxic action on epidermoid human larynx carcinomacells HEp-2 in vitro is shown to be due to the hydrogen peroxidegenerated by the combination of vitamins B12b and C. The drop inthe glutathione level preceding cell death was found to be the result ofcombined action of the vitamins. It is supposed that the induction of celldeath by combined action of vitamins B12b and C is connected to the damageof the cell redox system. |
| Keywords: | Vitamin B12b ascorbic acid cytotoxicity tumor cells hydrogen peroxide glutathione |
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