马尔尼菲篮状菌感染动物模型的研究进展

马尔尼菲篮状菌Talaromyces marneffei是一种温度双相性致病真菌,原名马尔尼菲青霉Penicillium marneffei。马尔尼菲篮状菌病是由马尔尼菲篮状菌感染引起的一种严重的深部真菌病,主要流行于东南亚地区,在我国主要以南方地区多见,该病与HIV/AIDS的流行有高度相关性。近年来,随着艾滋病发病率的上升,马尔尼菲篮状菌病的发病率呈逐年上升趋势。该病发病隐匿,病死率高,但致病机制尚不明确。动物模型能够为疾病的发病机理和临床治疗等研究提供充分有力的证据,本文综述了马尔尼菲篮状菌感染动物模型的研究进展,对几种新型的动物模型进行了探讨。

Recent advances in animal model experimentation in Talaromyces marneffei infection research

Talaromyces marneffei, formerly known as Penicillium marneffei, is a significant emerging pathogenic fungus in Southeast Asia which can cause life-threatening systemic infection. Most infections occurred in individuals with Human Immunodeficiency Virus (HIV), and the primarily reason for the increase in the number of cases is HIV pandemic. The pathogenesis of infection due to T. marneffei is unclear. Researchers often use animals for disease model studies to provide strong evidence for the pathogenesis and clinical treatment of the disease. This review summarizes the research on animal models of T. marneffei infection in recent years.