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Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta |
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| Authors: | Amarasinghe Kande K D Evdokimov Artem G Evidokimov Artem G Xu Kevin Clark Cynthia M Maier Matthew B Srivastava Anil Colson Anny-Odile Gerwe Gina S Stake George E Howard Brian W Pokross Matthew E Gray Jeffrey L Peters Kevin G |
| Institution: | Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. Amarasinghe.kk@pg.com |
| Abstract: | The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPbeta potency. |
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