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Effect of estrogens on apomorphine-induced circling behavior in the rat. |
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| Authors: | P Bédard J Dankova R Boucher P Langelier |
| Abstract: | The effect of administration of estrogens parenterally for 1 week was tested on apomorphine-induced circling in a group of castrated female rats with a lesion of the left entopednucluar nucleus. We observed a significant decrease in the number of turns per minute in estrogen-treated animals as compared with controls. Our tentative explanation is that estrogens decrease the sensitivity of dopamine receptors in the striatum. |
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