Allogenic stimulus induces prostaglandin and thromboxane production in T lymphocytes |
| |
| Authors: | A M Genaro G A Cremaschi E S Borda |
| |
| Institution: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN) Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina (CONICET), Buenos Aires. |
| |
| Abstract: | We have examined the influence of an allogeneic stimulus on T lymphocyte prostanoid synthesis. PGE2 and TXB2 (the stable product of TXA2) were determined by radioimmunoassay. When T cells were derived from alloimmunized animals, the production of PGE2 and TXA2 was significantly higher than that of non-immunized cells. Moreover, T immune lymphocytes in the presence of the immunized alloantigen showed an increment in prostanoid production. We propose that the allogeneic stimulus provides a signal to the T lymphocytes for an increase in prostanoid synthesis. |
| |
| Keywords: | |
|
