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Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease |
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| Authors: | Kauppinen Tiina M |
| Institution: | aDepartment of Neurology, University of California at San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA |
| Abstract: | Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the interest toward PARP-1 as a therapeutic target has peaked. This review introduces mechanism of PARP-1 activation, the role of PARP-1 in cell physiology and pathology, and discusses the potential of PARP-1 inhibition as a therapy in acute and chronic CNS diseases. |
| Keywords: | PARP-1 Neuronal death Inflammation DNA repair Neuroprotection |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |