A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast |
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| Authors: | Shaoxiao Wang Patrick J Horn Liang-Chun Liou Martin I Muggeridge Zhaojie Zhang Kent D Chapman Stephan N Witt |
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| Institution: | 1. Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA;2. Department of Biological Sciences, Center for Plant Lipid Research, University of North Texas, Denton, TX 76203, USA;3. Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA;4. Department of Microbiology and Immunology, Center for Molecular and Tumor Virology and the Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA |
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| Abstract: | Using a yeast model of Parkinson’s disease, we found that alpha-synuclein (αS) binds to lipid droplets in lipid-loaded, wild-type yeast cells but not to lipid droplets in lipid-loaded, peroxisome-deficient cells (pex3Δ). Our analysis revealed that pex3Δ cells have both fewer lipid droplets and smaller lipid droplets than wild-type cells, and that the acyl chains of the phospholipids on the surface of the lipid droplets from pex3Δ cells are on average shorter (C16) than those (C18) on the surface of lipid droplets from wild-type cells. We propose that the shift to shorter (C18 → C16) acyl chains contributes to the reduced binding of αS to lipid droplets in pex3Δ cells. |
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| Keywords: | Alpha-synuclein Lipid droplets Peroxisome Parkinson&rsquo s disease |
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