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Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa,not Bim |
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| Authors: | Tom Verfaillie Alexander van Vliet Abhishek D. Garg Michael Dewaele Noemi Rubio Sanjeev Gupta Peter de Witte Afshin Samali Patrizia Agostinis |
| Affiliation: | 1. Laboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Belgium;2. Laboratory of Pharmacology, KU Leuven, Belgium;3. Apoptosis Research Centre, NUI Galway, Ireland |
| Abstract: | |
| Keywords: | CHOP, C/EBP homologous protein eIF2a, eukaryotic initiation factor-2a ER, endoplasmic reticulum GRP78, glucose regulated protein 78 Hyp-PDT, hypericin-based photodynamic therapy ICD, immunogenic cell death MEF, murine embryonic fibroblast PERK, pancreatic ER kinase (PKR)-like ER kinase Phox, photo-oxidative ROS, reactive oxygen species UPR, unfolded protein response |
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