Vacuole biogenesis and protein transport to the plant vacuole: A comparison with the yeast vacuole and the mammalian lysosome |
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Authors: | D G Robinson G Hinz |
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Institution: | (1) Pflanzenphysiologisches Institut, Universität Göttingen, Untere Karspüle 2, D-37073 Göttingen, Germany |
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Abstract: | Summary The vacuole is often termed the lytic compartment of the plant cell. The yeast cell also possesses a vacuole containing acid hydrolases. In animal cells these enzymes are localized in the lysosome. Recent research suggests that there is good reason to regard these organelles as homologous in terms of protein transport. Although sorting motifs for the recognition of vacuolar proteins within the endomembrane system differ between the three organelles, there is an underlying similarity in targeting determinants in the cytoplasmic tails of Golgi-based receptors. In all three cases these determinants appear to interact with adaptins of clathrin-coated vesicles which ferry their cargo first of all to an endosomal compartment. The situation in sorting and targeting of plant vacuolar proteins is complicated by the fact that storage and lytic vacuoles may exist together in the same cell. The origin of these two types of vacuole is also a matter of some uncertanity.Abbrevations AP
assembly protein
- ALP
alkaline phosphatase
- ARF
adenosine diphosphate ribosylation factor
- BiP
immunoglobulin binding protein
- CCV
clathrin coated vesicle
- CPY
carboxypeptidase-Y
- DPAP
dipeptidyl aminopeptidase
- ER
endoplasmic reticulum
- GApp
Golgi apparatus
- LAMPs
lysosomal associated membrane protein(s)
- LAP
lysosomal acid phosphatase
- LIMPs
lysosomal integral membrane protein(s)
- MPRs
mannosyl 6-phosphate receptors
- MVB
multivesicular bodies
- NSF
N-ethylmaleimide sensitive fusion (protein)
- PAT
phosphinotricine acetyltransferase
- PB
protein body
- PHA
phytohemagglutinin
- PM
plasma membrane
- PSV
protein storage vacuole
- SNAPs
soluble NSF attachment protein(s)
- SNAREs
SNAP receptor(s)
- TGN
trans Golgi network
- TIP
tonoplast integral protein
- VPS
vacuolar protein sorting
- ZIO
zinc iodide/osmium |
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Keywords: | Clathrin coated vesicles Endosome Golgi apparatus Protein trafficking Vacuole |
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