Arthritis and Pain. Neurogenic origin of joint pain |
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Authors: | Jason J McDougall |
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Institution: | (1) Department of Physiology & Biophysics, Hospital Drive, University of Calgary, T2N 4N1 Calgary, Alberta, Canada |
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Abstract: | Arthritis pain affects millions of people worldwide yet we still have only a limited understanding of what makes our joints
ache. This review examines the sensory innervation of diarthroidal joints and discusses the neurophysiological processes that
lead to the generation of painful sensation. During inflammation, joint nerves become sensitized to mechanical stimuli through
the actions of neuropeptides, eicosanoids, proteinase-activated receptors and ion channel ligands. The contribution of immunocytes
to arthritis pain is also reviewed. Finally, the existence of an endogenous analgesic system in joints is considered and the
reasons for its inability to control pain are postulated. |
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Keywords: | |
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