Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion |
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Authors: | E-ri M Sol Meri Hovsepyan Peter Bergsten |
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Institution: | (1) Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden;(2) Institute of Molecular Biology of Armenian National Academy of Sciences, Yerevan, Armenia |
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Abstract: | Background Development of type 2 diabetes mellitus (T2DM) is characterized by aberrant insulin secretory patterns, where elevated insulin
levels at non-stimulatory basal conditions and reduced hormonal levels at stimulatory conditions are major components. To
delineate mechanisms responsible for these alterations we cultured INS-1E cells for 48 hours at 20 mM glucose in absence or
presence of 0.5 mM palmitate, when stimulatory secretion of insulin was reduced or basal secretion was elevated, respectively. |
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