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RNA polymerase II stalling: loading at the start prepares genes for a sprint |
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| Authors: | Jia Qian Wu Michael Snyder |
| Affiliation: | (1) Molecular, Cellular and Developmental Biology Department, Yale University, PO Box 208103, 06511 New Haven, CT, USA;(2) Molecular Biophysics and Biochemistry Department, Yale University, 06511, PO Box 208103, New Haven, CT, USA; |
| Abstract: | Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received. |
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