Two variants among Haemophilus influenzae serotype b strains with distinct bcs4, hcsA and hcsB genes display differences in expression of the polysaccharide capsule |
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| Authors: | Leo Schouls Han van der Heide Sandra Witteveen Bert Zomer Arie van der Ende Marina Burger Corrie Schot |
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| Affiliation: | (1) Laboratory for Infectious Diseases and Perinatal screening, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, 3721 Bilthoven, MA, The Netherlands;(2) Netherlands Vaccine Institute, Antonie van Leeuwenhoeklaan, Bilthoven, The Netherlands;(3) Netherlands Reference Laboratory for Bacterial Meningitis, Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands;(4) Laboratory for Toxicology, National Institute for Public Health and the Environment, Antonie van Leeuwenhoeklaan, Bilthoven, The Netherlands |
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| Abstract: | Background Despite nearly complete vaccine coverage, a small number of fully vaccinated children in the Netherlands have experienced invasive disease caused by Haemophilus influenzae serotype b (Hib). This increase started in 2002, nine years after the introduction of nationwide vaccination in the Netherlands. The capsular polysaccharide of Hib is used as a conjugate vaccine to protect against Hib disease. To evaluate the possible rise of escape variants, explaining the increased number of vaccine failures we analyzed the composition of the capsular genes and the expressed polysaccharide of Dutch Hib strains collected before and after the introduction of Hib vaccination. |
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