Adenylate kinase-independent thiamine triphosphate accumulation under severe energy stress in Escherichia coli |
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| Authors: | Tiziana Gigliobianco Bernard Lakaye Alexander F Makarchikov Pierre Wins Lucien Bettendorff |
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| Affiliation: | 1.Center for Cellular and Molecular Neurobiology,University of Liège,Liège,Belgium;2.Chemical Department,Grodno State Agricultural University,Grodno,Belarus |
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| Abstract: | Background Thiamine triphosphate (ThTP) exists in most organisms and might play a role in cellular stress responses. In E. coli, ThTP is accumulated in response to amino acid starvation but the mechanism of its synthesis is still a matter of controversy. It has been suggested that ThTP is synthesized by an ATP-dependent specific thiamine diphosphate kinase. However, it is also known that vertebrate adenylate kinase 1 catalyzes ThTP synthesis at a very low rate and it has been postulated that this enzyme is responsible for ThTP synthesis in vivo. |
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