Dermatoglyphic changes in human genetic disorders: preaxial defects of the upper limbs]

Dermatologlyphic prints of 9 patients with preaxial (radial) hand defects were compared with control ones. A correspondence is revealed between a decrease in thumb phalanx length and a respective decrease in ridge count, on the one hand, and between the 1st metacarpal hypo- or aplasia and a decrease in palmar ridge count between the metacarpo-phalangeal and thumb flexion creases, on the other hand. An interrelation is found between the anomalies in flexion crease and respective joint formation. It is suggested, that these disorders are due to genetically determined anomalies in morphogenetic gradients which control the distribution of positional information in upper limb morphogenetic field.