Binding and catalysis by yeast aldose reductase: a substrate-analog approach with new aldose derivatives. |
| |
| Authors: | P Hadwiger P Mayr A Tauss A E Stütz B Nidetzky |
| |
| Affiliation: | 1. Institut für Organische Chemie, Technische Universität Graz, Stremayrgasse 16, A-8010 Graz, Austria;2. Institut für Lebensmitteltechnologie, Universität für Bodenkultur, Muthgasse 18, A-1190 Vienna, Austria;1. School of Pharmaceutical Sciences, Rajiv Gandhi ProudyogikiVishwavidyalaya, Bhopal 462033, MP, India;2. Department of Pharmacology and Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, University of Toledo, OH, USA;3. ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, France;1. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China;2. State Key Laboratory for Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China;3. School of Life Sciences and Biotechnology and School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, PR China;4. Minhang Hospital, Shanghai Medical School of Fudan University, Shanghai, 201100, PR China;1. Biotechnology Department, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt;2. SeptivaK Research Group, Immunology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt;3. Special Projects Department, Bibliotheca Alexandrina, Alexandria, Egypt;4. Immunology and Allergy Department, Medical Research Institute, Alexandria University, Alexandria, Egypt;1. ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims, France;2. Laboratoire de Chimie Organique et de Substances Naturelles, Université Félix-Houphouët Boigny d’Abidjan-Cocody, 22 BP 582 Abidjan 22, Cote d’Ivoire;3. EA 4691, «Biomatériaux et inflammation en site osseux», Laboratoire de microbiologie, UFR de pharmacie, 1, rue du Maréchal-Juin, 51096 Reims, France;4. MEDyC UMR CNRS 7369, URCA, Faculté de Pharmacie, SFR CAP Santé, 1, rue du Maréchal-Juin, 51096 Reims, France |
| |
| Abstract: | 5-Deoxy-D-xylofuranose derivatives and a range of new 5,6-dideoxy analogs of D-glucofuranose bearing azido or fluoro substituents were synthesised and employed as substrates of the NADH-dependent aldehyde reduction catalysed by yeast aldose reductase. In terms of catalytic efficiencies, these products proved to be superior to the parent compounds. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
