Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate |
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Authors: | R F Derr K Draves M Derr |
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Affiliation: | Veterans Administration Medical Center, Research Service Minneapolis, Minnesota 55417, USA |
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Abstract: | Butyrate, lactate and beta-hydroxybutyrate, compounds which may be elevated in blood of ethanol dependent rats and substrates of the cerebral small-pool Krebs-cycle, were tested for their ability to suppress an ethanol withdrawal syndrome. Male Sprague-Dawley rats were rendered physically dependent on ethanol by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a 4-day period. Oral administration of a mixture of butyrate, lactate and beta-hydroxybutyrate was effective in suppressing the tremulous component of the ethanol withdrawal syndrome. |
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