Heterocyclic nucleoside analogues: design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles |
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| Authors: | Lee Yoon-Suk Kim Byeang Hyean |
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| Institution: | National Research Laboratory, Department of Chemistry, Center for Integrated Molecular Systems, Division of Molecular and Life Sciences, Pohang University of Science and Technology, 790-784, Pohang, South Korea. |
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| Abstract: | We have designed and synthesized novel antiviral nucleoside analogues, which consist of isoxazole rings as modified sugars and nucleobases (thymine, uracil, and 5-fluorouracil) with a methylene linker between them. These compounds represent a new class of modified nucleoside analogues and some of them show potent antiviral activities against Polio virus (Coxsackie B type 3 and Vesicular Stomatitis). |
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