Antimalarial activity of ferrocenyl chalcones |
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| Authors: | Wu Xiang Wilairat Prapon Go Mei-Lin |
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| Institution: | Department of Pharmacy, National University of Singapore, 18, Science Drive 4, Singapore 117543, Singapore. |
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| Abstract: | A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC(50) of 4.5 and 5.1 microM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. |
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