Neurotoxicity of acrylamide in rats. I. Subacute intoxication. Absence of effect on incorporation of plasma phosphates into the acid-soluble phosphates of the sciatic nerve and the gastrocnemius muscle, in anatomic continuity and after neural section]

The subcutaneous injection of acrylamide (30 mg kg-1 day-1) in adult male rats induces a severe impairment of the general state of health and a progressive polyneuropathy at the cumulative dose of 180 mg/kg. At the cumulative dose of 400 mg acrylamide does not interfere with the incorporation of plasma inorganic phosphate into the inorganic and organic acid-soluble phosphate fractions of either the gastrocnemius muscle or the sciatic nerve Schwann cells. Nor does it modify the characteristic metabolic response of these fractions to Wallerian degeneration and neurogenic muscle atrophy.