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The discovery and validation of new drug targets in cancer |
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| Authors: | Sara A Courtneidge Greg D Plowman |
| Institution: | SUGEN Inc., 230 East Grand Avenue, South San Francisco, CA 94080, USA |
| Abstract: | Advances in our understanding of the signal transduction pathways involved in cellular growth control have provided several new strategies for cancer therapy. Recent advances now make it possible to develop selective inhibitors targeting genomic instability, the growth, survival, and invasion of the tumor, and its nourishment through the growth of new blood vessels. |
| Keywords: | Abbreviations: DDR discoidin domain receptor IGF1 insulin-like growth factor 1 IGF1R IGF1 receptor ILK integrin-linked kinase PDK 3-phosphoinositide-dependent protein kinase PH pleckstrin homology PI3-K phosphatidylinositol 3-kinase |
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