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1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems |
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| Authors: | Gelmi Maria Luisa Caputo Francesco Clerici Francesca Pellegrino Sara Giannaccini Gino Betti Laura Fabbrini Laura Schmid Lara Palego Lionella Lucacchini Antonio |
| Institution: | aIstituto di Chimica Organica “A. Marchesini”, Facoltà di Farmacia, Università di Milano, Via Venezian 21, I-20133 Milano, Italy bDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Via Bonanno 6, Pisa, Italy |
| Abstract: | Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system. |
| Keywords: | Aminocyclopentane-1 2 4-tricarboxylic acids Chemical resolution Serotoninergic receptors Glutamatergic receptors |
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