Evolution of the relaxin-like peptide family |
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| Authors: | Tracey?N?Wilkinson Terence?P?Speed Geoffrey?W?Tregear Email author" target="_blank">Ross?AD?BathgateEmail author |
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| Institution: | (1) Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Australia;(2) Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia |
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| Abstract: | Background The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence
similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3,
INSL4, INSL5, INSL6 remain uncharacterised. The evolution of this family has been contentious; high sequence variability is
seen between closely related species, while distantly related species show high similarity; an invertebrate relaxin sequence
has been reported, while a relaxin gene has not been found in the avian and ruminant lineages. |
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