The frequency and distribution of sister chromatid exchanges in human chromosomes |
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| Authors: | William F. Morgan Peter E. Crossen |
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| Affiliation: | (1) Department of Human Genetics, State University of Leiden, Wassenaarseweg 72, Leiden, The Netherlands;(2) Institut für Humangenetik der Universität Münster, D-4400 Münster, Federal Republic of Germany |
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| Abstract: | Summary A detailed procedure is described for a rapid detection of phosphoglucomutase-2 (=phosphopentomutase; PGM-2) on Cellogel following electrophoresis of extracts of human red blood cells and other tissues, including cultured fibroblasts and various types of primate-rodent somatic hybrid cells.The present study indicated that there is only one locus for phosphopentomutase in man. The data from a selected panel of 20 independent clones of man-mouse somatic cell hybrids, investigated for the presence of human chromosomes and for the presence or absence of human PGM-2 favored the assignment of the human PGM-2 locus to chromosome 4. |
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