A drug based on water-ethanol extract of oyster mushroom mycelium displays hepatoprotective properties in experimental model of steatohepatitis |
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| Authors: | V Yu Polyakov S A Golyshev G I Kir’yanov E A Arifulin V P Gerasimenya S V Zakharov K Z Gumargalieva Yu L Putirsky |
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| Institution: | 1.Belozersky Institute of Physico-chemical Biology,Lomonosov Moscow State University,Moscow,Russia;2.LLC “Inbiopharm”,Moscow,Russia;3.Semenov Institute of Chemical Physics,Russian Academy of Sciences,Moscow,Russia;4.Alexandrov Center for Oncology and Medical Radiology,Minsk,Belarus |
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| Abstract: | Nonalcoholic steatohepatitis in rats induced by the high-fat diet was used as an experimental model for testing hepatoprotective
properties of drug based on water-ethanol extract from oyster mushroom mycelium. Progression of pathology development was
monitored histologically and by biochemical assay of blood samples. Subcellular response was analyzed using electron microscopy.
It was shown that administration of the high-fat diet for 14 days leads to a development of adipose degeneration of liver
(steatosis). Histological evidences were confirmed biochemically. Alkaline phosphatase, bilirubin, free cholesterol and lowdensity
lipoprotein cholesterol levels were increased in blood of experimental animals in comparison to control. Administration of
the drug was performed in parallel with high-fat food. It was shown that pathological alterations of liver in this case were
reduced at both organ and cellular levels. Cholesterol and triglyceride levels were close to those in control animals. The
data obtained confirm that the drug assayed can be used in clinical practice for prevention and treatment of nonalcoholic
steatohepatitis. |
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