Disseminated histoplasmosis with lesions restricted to the larynx in a patient with AIDS. Report of a case and review of the literature |
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Authors: | Solari Rubén Corti Marcelo Cangelosi Diana Escudero Manuel Negroni Ricardo Saccheri Christian Schtirbu Ricardo |
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Institution: | 1. Division de HIV/SIDA, Hospital de Enfermedades Infecciosas F. J. Muñiz, Buenos Aires, Argentina;2. Laboratorio de Micología, Hospital de Enfermedades Infecciosas F. J. Muñiz, Buenos Aires, Argentina;3. Servicio de Otorrinolaringología, Hospital de Enfermedades Infecciosas F. J. Muñiz, Buenos Aires, Argentina;4. Laboratorio de Histopatología, Hospital de Enfermedades Infecciosas F. J. Muñiz, Buenos Aires, Argentina |
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Abstract: | Histoplasmosis is an endemic and systemic mycosis, caused by the dimorphic fungus Histoplasma capsulatum var capsulatum. Disseminated disease in immunocompromised patients generally results from the reactivation of latent foci after a prolonged period of asymptomatic infection. We report a case of laryngeal histoplasmosis as the unique clinical manifestation of a progressive form of the disease in a patient with advanced HIV/AIDS disease. Histopathological analysis of laryngeal biopsy smears revealed granulomas containing Histoplasma-like organisms. Treatment with amphotericin B followed by itraconazole resulted in complete remission of laryngeal lesions. To our knowledge, this is the third case report of laryngeal histoplasmosis in a patient with AIDS. |
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