Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK |
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| Authors: | Unterseher Frank Hefele Joerg A Giehl Klaudia De Robertis Eddy M Wedlich Doris Schambony Alexandra |
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| Institution: | 1.Universität Karlsruhe, Zoologisches Institut II, Karlsruhe, Germany;2.Universität Ulm, Abteilung Pharmakologie und Toxikologie, Ulm, Germany;3.Howard Hughes Medical Institute, University of California, Los Angeles, CA, USA |
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| Abstract: | Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively promotes convergence in CE movements. XPAPC signals through the small GTPases Rho A and Rac 1 and c-jun N-terminal kinase (JNK). Loss of XPAPC function blocks Rho A-mediated JNK activation. Despite common downstream components, XPAPC and Wnt/PCP signalling are not redundant, and the activity of both, XPAPC and PCP signalling, is required to coordinate CE movements. |
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| Keywords: | convergent extension JNK planar cell polarity Rho A XPAPC |
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