Expression of candidate pheromone receptor genes in vomeronasal neurons |
| |
Authors: | Dulac C; Axel R |
| |
Institution: | Howard Hughes Medical Institute, Cambridge, MA, USA. dulac@fas.harvard.edu |
| |
Abstract: | In mammals, olfactory sensory perception is mediated by two anatomically
and functionally distinct organs: the main olfactory epithelium (MOE) and
the vomeronasal organ (VON). Pheromones activate the VNO and elicit a
characteristic array of innate reproductive and social behaviors, along
with dramatic neuroendocrine responses. Recent approaches have provided new
insights into the molecular biology of sensory transduction in the VNO.
Differential screening of cDNA libraries constructed from single sensory
neurons from the rat VNO has led to the isolation of a family of genes
which are likely to encode mammalian pheromone receptors. The isolation of
these receptors from the VNO might permit the analysis of the molecular
events which translate the bindings of pheromones into innate stereotypic
behaviors and help to elucidate the logic of pheromone perception in
mammals.
|
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|