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Spontaneous and experimental hepatitis A in Old World monkeys |
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| Authors: | Z V Shevtsova B A Lapin N V Doroshenko R I Krilova L I Korzaja I B Lomovskaya Z N Dzhelieva G K Zairov V M Stakhanova E G Belova |
| Institution: | Institute of Experimental Pathology and Therapy, USSR Academy of Medical Sciences, Sukhumi, Moscow. |
| Abstract: | Virologic, serologic, biochemical, and morphological data characterizing spontaneous hepatitis A (HA) in cynomolgus macaques (Macaca fascicularis) and green monkeys (Cercopithecus aethiops) are reported. Experimental HA was induced in macaques as a result of infection with human hepatitis A virus (HAV-h). Disease similar to human HA was induced in cynomolgus macaques by HAV isolates from spontaneously sick rhesus (M. mulatta) and green monkeys. This experimental model of HA in macaques can be used for vaccine and anti-viral preparation testing. |
| Keywords: | Hepatitis A Macaca fascicularis M mulatta Cercopithecus aethiops Experimental hepatitis Spontaneous hepatitis |