Longitudinal and lateral variations in the aluminum concentration of selected caprine, bovine, and human bone samples |
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Authors: | Shida Tang Patrick J Parsons Daniel Perl |
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Institution: | (1) New York State Department of Health, Wadsworth Center, P.O. Box 509, 12201-0509 Albany, NY;(2) Department of Environmental Health and Toxicology, School of Public Health, State University of New York at Albany, 12201-0509 Albany, NY;(3) Division of Neuropathology, Mount Sinai Medical Center, 10029 New York, NY |
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Abstract: | Longitudinal and lateral variations in Al concentration in several large animal (bovine and caprine) long bones (tibia and
femur) and several human clavicle bones were examined using a sensitive analytical method based on electrothermal atomization
atomic absorption spectrometry with Zeeman background correction. Bone segments were carefully removed using special tools
free of significant Al contamination, freeze-dried, and digested overnight at room temperature in concentrated HNO3. Bone digestates were analyzed for Al using simple aqueous calibration standards with a Ca(NO3)2 modifier. Mean bone Al concentrations were relatively low (<1 Μg/g, dry weight) in bovine and caprine long bones compared
to literature values for human bone samples. Longitudinal variations of Al in the animal bones examined appeared relatively
uniform compared to the human clavicle bones, where, in three of five cases, Al appeared enriched at the epiphyses (joints).
The Al “enrichment” was symmetrical with respect to both left and right clavicle bones. Aluminum concentrations at the mid-shaft
of the clavicle bone show less variation compared to whole bone studies, but considerable scatter is evident along the bone
length. The mean bone aluminum concentration in the five human subjects varied from 1 to 6 Μ/g dry weight. |
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Keywords: | Aluminum distribution bone analysis electrothermal atomization-atomic absorption spectrometry microwave digestion |
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