Null alleles at two lactate dehydrogenase loci in rainbow trout are associated with decreased developmental stability |
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Authors: | Robb F Leary Fred W Allendorf Kathy L Knudsen |
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Institution: | (1) Division of Biological Sciences, University of Montana, 59812 Missoula, MT, USA |
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Abstract: | Previous studies with rainbow trout (Oncorhynchus mykiss) have shown that allozymic heterozygotes have increased developmental stability, as measured by reduced fluctuating bilateral
asymmetry. In this paper, we examine the phenotypic effects of null alleles at two lactate dehydrogenase (LDH) loci. If the
association between allozymic heterozygosity and developmental stability is due largely to linked chromosomal segments, then
we would expect null allele heterozygotes to have increased developmental stability. In contrast, heterozygotes for LDH null
alleles in three populations have reduced developmental stability. This suggests that the reduction in enzyme activity at
these loci is having a deleterious effect on development that is strong enough to mask any beneficial effects that may be
associated with heterozygosity for these chromosomal segments. The LDH loci examined in this study are members of two different
paralogous pairs of duplicate genes produced by the polyploidization of the ancestral salmonid genome. The apparent deleterious
effects of these null alleles in heterozygotes could retard the possible loss of duplicate gene expression. |
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Keywords: | bilateral asymmetry null allele gene duplication polyploidy salmonid |
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