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Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation |
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| Authors: | Hasvold Lisa A Wang Weibo Gwaltney Stephen L Rockway Todd W Nelson Lissa T J Mantei Robert A Fakhoury Stephen A Sullivan Gerard M Li Qun Lin Nan-Horng Wang Le Zhang Haiying Cohen Jerome Gu Wen-Zhen Marsh Kennan Bauch Joy Rosenberg Saul Sham Hing L |
| Affiliation: | Pharmaceutical Discovery, R-47B, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. lisa.hasvold@abbott.com |
| Abstract: | Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed. |
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