Effect of neuropeptide Y microinjected into the hypothalamus on ethanol consumption |
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| Authors: | Lucas L A C McMillen B A |
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| Institution: | Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27838, USA |
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| Abstract: | Guide cannula were implanted in rats aimed at the paraventricular nucleus (PVN) of the hypothalamus for microinjection of neuropeptide Y (NPY), D-NPY27–36, or vehicle. In the Wistar rat, there was no significant effect on the consumption of ethanol. In Myers’ high ethanol preferring (mHEP) rats, D-NPY27–36 caused a significant 54% decrease in ethanol consumption from baseline, but the response was not different from vehicle. NPY-induced feeding in satiated Wistar rats, was blocked by a Y1 receptor antagonist, D-NPY27–36. D-NPY27–36 decreased 78% feeding in food-deprived rats. Thus, neither the Wistar nor the mHEP rat perceives ethanol as a source of calories comparable to food. |
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| Keywords: | NPY or neuropeptide Y Caloric intake Drinking behavior PVN or paraventricular nucleus |
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