The effects of short-chain fatty acids on the neuronal membrane functions ofHelix pomatia. III.22Na efflux from the cells |
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Authors: | Alexandr A Saghyan Senorik S Dadalian Toshifumi Takenaka Mirik A Suleymanian Sinerik N Ayrapetyan |
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Institution: | 1. Laboratory of Biomembranology, Institute of Experimental Biology, Academy of Sciences of Armenian SSR, Hasratyan 7, 375044, Yerevan, Russia 2. Department of Physiology, Yokohama City University, 232, Minamiku, Yokohama, Japan
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Abstract: | The effect of short-chain fatty acids on both ouabain-sensitive and ouabain-insensitive fractions of 22Na efflux from the neurons of Helix pomatia was studied. Fatty acids, having fewer than 10 carbon atoms in the hydrocarbon chain, increased the ouabain-sensitive 22Na efflux from the neurons, while fatty acids, having more than 9 carbon atoms, inhibited the 22Na efflux in comparison with that in normal physiological solution. All the fatty acids used had an inhibiting effect on the ouabain-insensitive 22Na efflux from the cells independent on the number of carbon atoms in the hydrocarbon chain. These studies indicate that these short-chain fatty acids can be effective modulators of both ouabain-sensitive and ouabain-insensitive fractions of Na efflux from the cells. |
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