纳米药物与肿瘤转移的种子-土壤学说

肿瘤细胞在体内从原发灶向远处转移是恶性肿瘤最重要的生物学特征之一,严重影响了临床治疗效果,成为肿瘤患者死亡的主要原因。掌握转移过程中各个阶段的特征和影响因素,对阻止肿瘤转移的发生,以及改善肿瘤患者的愈后意义重大。肿瘤转移的种子-土壤学说从肿瘤细胞本身的特性、转移位点处的微环境及两者的相互作用对转移过程可能的机制进行阐述。纳米抗癌药物由于其独特的理化和生物学性质,应用于恶性肿瘤的治疗前景广阔。我们结合纳米药物的作用原理与肿瘤转移的种子-土壤学说之间的关系,对纳米药物治愈恶性肿瘤的可能性进行综述。

The Seed and Soil Theory of Tumor Metastasis and Nano-Drugs Against Cancer

Cancer cells＇ distant metastasis from the primary tumor is one of the most important biological char-acteristics of malignant tumor.It causes a serious impact on clinical therapeutic effect and becomes the primary cause of the death of tumor patients.Handling the features and influencing factors of various stages in the progress of metastasis is significant to prevent the occurrence of tumor metastasis and to enable better patient recovery.The seed and soil theory expounds the probable mechanism of metastasis in the view of the characteristic of cancer cells、the microenvironment of distinct target organs and the interactions between them.Nanomedicine＇s unique physical,chemistry and biological qualities promote it a nice therapeutic method to treat malignant tumors.We reviewed the possiblility of nanomedicine in charming of the malignancy refering to the seed and soil theory and the application of nanotechnology in the domain of antitumor therapeutics.