Rostro-caudal patterning of receptor-expressing olfactory neurones in the rat nasal cavity |
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Authors: | J. Strotmann L. Wanner T. Helfrich A. Beck H. Breer |
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Affiliation: | (1) Institute of Zoophysiology, University Stuttgart-Hohenheim, Garbenstrasse 30, D-70599 Stuttgart, Germany |
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Abstract: | The rostro-caudal extent of odorant receptor expression zones in the rat olfactory epithelium was analysed by means of in situ hybridization. Three broad non-overlapping zones were identified that extended along almost the entire anterior-posterior axis; each zone was composed of several separate bands running anterior to posterior throughout the olfactory epithelium. Superimposed onto these broad zones was the expression area of a particular receptor subtype (OR37); it was restricted to a small region of the epithelial sheet with a high density of reactive neurones in the centre and declining numbers towards the periphery of the region. A quantitative evaluation of the reactive cells revealed that, despite their diferent distribution patterns, all receptor subtypes were expressed in an equal number of neurones. |
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Keywords: | Olfactory epithelium Sensory cells Hybridization, in situ Rat (Wistar) |
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