Exposure to nuclear magnetic resonance imaging procedure attenuates morphine-induced analgesia in mice |
| |
| Authors: | K P Ossenkopp M Kavaliers F S Prato G C Teskey E Sestini M Hirst |
| |
| Institution: | 1. Departments of Psychology, St. Joseph''s Hospital, University of Western Ontario, London, Ontario, Canada N6A 5C2;2. Department of Zoology, St. Joseph''s Hospital, University of Western Ontario, London, Ontario, Canada N6A 5C2;3. Departments of Pharmacology and Toxicology and the Division of Oral Biology, St. Joseph''s Hospital, University of Western Ontario, London, Ontario, Canada N6A 5C2;4. The Research Institute St. Joseph''s Hospital, University of Western Ontario, London, Ontario, Canada N6A 5C2;5. Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9 |
| |
| Abstract: | Adult male mice exposed to a Nuclear Magnetic Resonance Imaging (NMRI) procedure during the mid-dark period and injected with morphine (10 mg/kg) failed to exhibit the normal nocturnally enhanced morphine analgesia response to a thermal stimulus that was displayed by mice exposed to a sham imaging procedure and treated with morphine (p less than .01). When tested during the mid-light period, animals exposed to the NMRI procedure and given morphine displayed attenuated analgesia levels relative to sham exposed mice (p less than .01) treated with morphine. However, the morphine induced analgesia was not totally abolished since the imaged mice still exhibited analgesia relative to saline treated mice (p less than .01). These results suggest that the magnetic and/or radio-frequency fields associated with the NMRI procedure alter both day- and night-time responses to morphine. These results may reflect magnetic field induced alterations in neuronal calcium binding and/or alterations in nocturnal pineal gland activity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
