Cellular events in tolerance. II. Thymus-bone marrow cell cooperation in the immune response to BSA in Wistar Furth rats |
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| Authors: | J M Phillips-Quagliata C Wertenbaker D O Bensinger F Quagliata |
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| Institution: | Department of Pathology and the Rheumatic Diseases Study Group, Department of Medicine New York University School of Medicine New York, New York 10016 U.S.A. |
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| Abstract: | Normal bone marrow cells from Wistar Furth rats were competent to transfer immune responsiveness to bovine serum albumin to thymectomised, irradiated, syngeneic recipients. When the bone marrow cells were taken from donors thymectomised early in life they were incompetent, but competence was restored by addition of normal thymus cells. It was concluded that normal Wistar Furth bone marrow cells contain some thymus-derived cells. Thymus cells from tolerant donors were less effective in cooperation with bone marrow cells, however the thymus cells appeared less tolerant than their donors. |
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