Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population |
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Authors: | Bulut H Pehlivan M Alper S Tomatir A G Onay H Yüksel S E Ozkinay F Pehlivan S |
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Affiliation: | Department of Biology, Faculty of Science, Ege University, Izmir, Turkey. |
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Abstract: | Accumulation of hydrogen peroxide (H(2)O(2)) and low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo patients. We investigated a possible association between the CAT exon 9 (Asp-389) gene and vitiligo susceptibility in the Turkish population. Thirty-four patients with vitiligo and 49 gender, age and ethnic matched controls were enrolled in the study. Genotyping was done by PCR-RFLP. The CAT exon 9 (Asp-389) genotype and allele frequencies of vitiligo patients did not differ significantly from those of healthy controls. We found no association between CAT (Asp-389) gene polymorphism and vitiligo susceptibility in Turkish vitiligo patients. |
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