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Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity |
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| Authors: | Clader John W Billard William Binch Herbert Chen Lian-Yong Crosby Gordon Duffy Ruth A Ford Jennifer Kozlowski Joseph A Lachowicz Jean E Li Shengjian Liu Charles McCombie Stuart W Vice Susan Zhou Gowei Greenlee William J |
| Institution: | Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. john.clader@spcorp.com |
| Abstract: | Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity. |
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