Internal Ribosome Entry Sites within the RNA Genomes of Hepatitis C Virus and Other Flaviviruses |
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| Institution: | 1. Single Molecule Analysis Group, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA;2. Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI 48109-1055, USA;3. Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109-1055, USA |
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| Abstract: | The 5′ nontranslated RNAs of hepatitis C virus (HCV) and several other members of theFlaviviridaecontain highly structured segments which form internal ribosome entry sites (IRESs). Thesecis-active RNA elements direct the cap-independent initiation of translation of the viral polyprotein in association withtrans-acting cellular and possibly viral proteins, and thus they play a key role in the replication of the virus. The structure of the HCV IRES does not resemble that of any picornaviral IRES, and its function is uniquely dependent upon RNA sequence extending 3′ of the site of translation initiation as well as structure surrounding the initiator AUG. |
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